Isochromosome 7q: the primary cytogenetic abnormality in hepatosplenic γδ T cell lymphoma
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چکیده
منابع مشابه
Challenges and new prospects in hepatosplenic γδ T-cell lymphoma.
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoid neoplasms characterized by aggressive clinical behavior and dismal prognosis. Hepatosplenic γδ T-cell lymphoma (γδ-HSTL) is a particular form of PTCL that arises from a small subset of γ/δ T-cell receptor-expressing lymphocytes. γδ-HSTL has a rapidly progressive course and poor outcome due also to its refractoriness to co...
متن کاملHepatosplenic γδ T-cell Lymphoma is a Rare Clinicopathologic Entity with Poor Outcome: Report on a Series of 21 Cases. Short title: HEPATOSPLENIC γδ T-CELL LYMPHOMA
We report on the characteristics of 21 cases of Hepatosplenic γδ T-cell lymphoma (HSγδTCL), an entity recognized since 1994 by the REAL classification. Median age was 34 years. Patients presented with splenomegaly (n=21), hepatomegaly (n=15) and thrombocytopenia (n=20). Histopathologic findings were homogeneous with the presence of medium-sized lymphoma cells within the sinusoids of splenic red...
متن کاملPrimary Hepatosplenic Large B-Cell Lymphoma
Diffuse large B-cell lymphoma is the most common form of lymphoma. It usually begins in the lymph nodes; up to 40% may have an extranodal presentation. According to a definition of primary extranodal lymphoma with presentation only in extranodal sites, there are reports of large B-cell lymphomas limited to liver or spleen as separate entities, and to date there have been only three documented c...
متن کاملHepatosplenic T-cell lymphoma: A case series.
Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of Non-Hodgkin Lymphoma (NHL), grouped under the mature or peripheral T-cell lymphomas. It is characterised by extranodal infiltration and proliferation of malignant T-cells within the sinusoids of the liver, sinuses and red pulp of the spleen, and the bone marrow. The tumour cells express CD2 and CD3, but are CD4, CD5 and CD8 negative and ex...
متن کاملLiterature Review : Hepatosplenic T - cell Lymphoma
Hepatosplenic T-cell lymphoma (HSTCL) is a rare type of T-cell lymphoma with poor clinical outcomes. Typical clinical features include a predominance of young male with fever, hepatosplenomegaly and cytopenia with the absence of appreciable lymphadenopathy. Diagnosis is based on examination of peripheral blood and histopathology of bone marrow, spleen or liver. In addition, immunophenotyping an...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1997
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2400742